Author: ["Christopher Weidenmaier","John F Kokai-Kun","Sascha A Kristian","Tanya Chanturiya","Hubert Kalbacher","Matthias Gross","Graeme Nicholson","Birgid Neumeister","James J Mond","Andreas Peschel"]
CITE.CC academic search helps you expand the influence of your papers.
Abstract
Colonization of the anterior nares in ∼37% of the population is a major risk factor for severe Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface-exposed staphylococcal polymer, is essential for nasal colonization and mediates interaction with human nasal epithelial cells. WTA-deficient mutants were impaired in their adherence to nasal cells, and were completely unable to colonize cotton rat nares. This study describes the first essential factor for S. aureus nasal colonization.Cite this article
Weidenmaier, C., Kokai-Kun, J., Kristian, S. et al. Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections. Nat Med 10, 243–245 (2004). https://doi.org/10.1038/nm991 