Author: ["Rajnish A Gupta","Dingzhi Wang","Sharada Katkuri","Haibin Wang","Sudhansu K Dey","Raymond N DuBois"]
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Abstract
We treated Apcmin mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator–activated receptor-δ (PPAR-δ). Exposure of Apcmin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.Cite this article
Gupta, R., Wang, D., Katkuri, S. et al. Activation of nuclear hormone receptor peroxisome proliferator–activated receptor-δ accelerates intestinal adenoma growth. Nat Med 10, 245–247 (2004). https://doi.org/10.1038/nm993 