Author: ["Terrie E Taylor","Wenjiang J Fu","Richard A Carr","Richard O Whitten","Jeffrey G Mueller","Nedson G Fosiko","Susan Lewallen","N George Liomba","Malcolm E Molyneux"]
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Abstract
To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.Cite this article
Taylor, T., Fu, W., Carr, R. et al. Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med 10, 143–145 (2004). https://doi.org/10.1038/nm986 