Author: ["Florence Buseyne","Sylvie Le Gall","Claire Boccaccio","Jean-Pierre Abastado","Jeffrey D. Lifson","Larry O. Arthur","Yves Rivière","Jean-Michel Heard","Olivier Schwartz"]
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Abstract
Dendritic cells and macrophages can process extracellular antigens for presentation by MHC-I molecules. This exogenous pathway may have a crucial role in the activation of CD8+ cytotoxic T lymphocytes during human viral infections. We show here that HIV-1 epitopes derived from incoming virions are presented through the exogenous MHC-I pathway in primary human dendritic cells, and to a lower extent in macrophages, leading to cytotoxic T-lymphocyte activation in the absence of viral protein synthesis. Exogenous antigen presentation required adequate virus-receptor interactions and fusion of viral and cellular membranes. These results provide new insights into how anti-HIV cytotoxic T lymphocytes can be activated and have implications for anti-HIV vaccine design.Cite this article
Buseyne, F., Gall, S., Boccaccio, C. et al. MHC-I–restricted presentation of HIV-1 virion antigens without viral replication. Nat Med 7, 344–349 (2001). https://doi.org/10.1038/85493 