Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancem
Author: ["Kang Chen","Ildiko Aradi","Niklas Thon","Mariam Eghbal-Ahmadi","Tallie Z. Baram","Ivan Soltesz"]
Publication: Nature Medicine
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Abstract
Febrile seizures are the most common type of developmental seizures, affecting up to 5% of children. Experimental complex febrile seizures involving the immature rat hippocampus led to a persistent lowering of seizure threshold despite an upregulation of inhibition. Here we provide a mechanistic resolution to this paradox by showing that, in the hippocampus of rats that had febrile seizures, the long-lasting enhancement of the widely expressed intrinsic membrane conductance Ih converts the potentiated synaptic inhibition to hyperexcitability in a frequency-dependent manner. The altered gain of this molecular inhibition–excitation converter reveals a new mechanism for controlling the balance of excitation–inhibition in the limbic system. In addition, here we show for the first time that h-channels are modified in a human neurological disease paradigm.
Cite this article
Chen, K., Aradi, I., Thon, N. et al. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med 7, 331–337 (2001). https://doi.org/10.1038/85480
