➦   Notch3 signaling promotes the development of pulmonary arterial hypertension

➦   Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines

➦   Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation f

➦   Extracellular histones are major mediators of death in sepsis

➦   Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopat

➦   Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy

➦   Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

➦   Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

➦   Modulating hedgehog signaling can attenuate the severity of osteoarthritis

➦   Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neuro

➦   A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–de

➦   A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

➦   Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries

➦   Comprehensive genomic access to vector integration in clinical gene therapy

➦   Enhanced tonic GABAA inhibition in typical absence epilepsy

➦   Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

➦   Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently

➦   Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosi

➦   A mitotic transcriptional switch in polycystic kidney disease

➦   NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen pre

➦   Salt-sensitive hypertension in circadian clock–deficient Cry-null mice involves dysregulated adrenal

➦   Platelets contribute to postnatal occlusion of the ductus arteriosus

➦   Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological

➦   Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by

➦   Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendriti

➦   Real-time imaging reveals the single steps of brain metastasis formation

➦   Characterization of the human neutrophil alloantigen-3a

➦   A key role for orexin in panic anxiety

➦   Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

➦   Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease

➦   Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

➦   Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitutio

➦   Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

➦   Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly

➦   Transferrin therapy ameliorates disease in β-thalassemic mice

➦   The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pr

➦   Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast c

➦   Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene ther

➦   Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of

➦   A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infe

➦   Innate immune lectins kill bacteria expressing blood group antigen

➦   Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment

➦   An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ra

➦   Pharmacological correction of a defect in PPAR-γ signaling ameliorates disease severity in Cftr-defi

➦   Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lym

➦   Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse H

➦   Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal

➦   Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

➦   Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation dur

➦   Kynurenine is an endothelium-derived relaxing factor produced during inflammation