➦   A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

➦   Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

➦   Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

➦   Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

➦   Regulation of endocytosis via the oxygen-sensing pathway

➦   Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic

➦   Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promot

➦   Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

➦   Molecular therapy of obesity and diabetes by a physiological autoregulatory approach

➦   A new role of substance P as an injury-inducible messenger for mobilization of CD29+ stromal-like ce

➦   Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from m

➦   Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

➦   Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory in

➦   Bioluminescence imaging of myeloperoxidase activity in vivo

➦   House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cel

➦   Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitor

➦   Induction of natural killer T cell–dependent alloreactivity by administration of granulocyte colony–

➦   Estrogen-dependent and C-C chemokine receptor-2–dependent pathways determine osteoclast behavior in

➦   Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

➦   Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

➦   The parametric response map is an imaging biomarker for early cancer treatment outcome

➦   Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens

➦   Chromosome instability is common in human cleavage-stage embryos

➦   Histone H2AX is integral to hypoxia-driven neovascularization

➦   Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunothera

➦   Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the br

➦   A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolari

➦   Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

➦   Synthetic EthR inhibitors boost antituberculous activity of ethionamide

➦   Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth facto

➦   Inhibition of osteoblastic bone formation by nuclear factor-κB

➦   Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II–induced aorti

➦   Impaired gastric acidification negatively affects calcium homeostasis and bone mass

➦   Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV

➦   Netting neutrophils in autoimmune small-vessel vasculitis

➦   Prophylactic treatment with sialic acid metabolites precludes the development of the myopathic pheno

➦   A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

➦   Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cel

➦   Biomechanical regulation of blood vessel growth during tissue vascularization

➦   Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH1

➦   Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–de

➦   Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple

➦   GOAT links dietary lipids with the endocrine control of energy balance

➦   Validated germline-competent embryonic stem cell lines from nonobese diabetic mice

➦   Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaque

➦   Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain

➦   A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates

➦   Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

➦   HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

➦   CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progres