➦   Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation

➦   A futile metabolic cycle activated in adipocytes by antidiabetic agents

➦   Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and a

➦   Activation and function of cyclin T–Cdk9 (positive transcription elongation factor-b) in cardiac mus

➦   Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis

➦   Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated prot

➦   Functional PPAR-γ receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas

➦   Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and in

➦   Migration through host cells activates Plasmodium sporozoites for infection

➦   Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

➦   Serum insulin-like growth factor I regulates brain amyloid-β levels

➦   Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease

➦   β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

➦   A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth

➦   Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

➦   Induction of angiogenesis in a mouse model using engineered transcription factors

➦   T cells require TRAIL for optimal graft-versus-tumor activity

➦   Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

➦   An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal i

➦   Hypothalamic insulin signaling is required for inhibition of glucose production

➦   Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

➦   The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene

➦   Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativit

➦   Modulation of anxiety through blockade of anandamide hydrolysis

➦   In vivo imaging of transcriptionally active estrogen receptors

➦   Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

➦   Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity

➦   Cytokine traps: multi-component, high-affinity blockers of cytokine action

➦   Melusin, a muscle-specific integrin β1–interacting protein, is required to prevent cardiac failure i

➦   Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways

➦   Therapeutic dendritic-cell vaccine for simian AIDS

➦   Human and porcine early kidney precursors as a new source for transplantation

➦   The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

➦   Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells

➦   Progranulin is a mediator of the wound response

➦   Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

➦   Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive

➦   HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and

➦   Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with

➦   VEGF: A modifier of the del22q11 (DiGeorge) syndrome?

➦   Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuropr

➦   Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

➦   Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by C

➦   PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

➦   RNA interference targeting Fas protects mice from fulminant hepatitis

➦   The thrombomodulin–protein C system is essential for the maintenance of pregnancy

➦   Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells

➦   Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HI

➦   Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating

➦   Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic