➦   Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation

➦   A new transgene reporter for in vivo magnetic resonance imaging

➦   Calmodulin kinase II inhibition protects against structural heart disease

➦   Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease

➦   Apolipoprotein M is required for preβ-HDL formation and cholesterol efflux to HDL and protects again

➦   A chimeric human-cat fusion protein blocks cat-induced allergy

➦   Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional id

➦   An essential function for NBS1 in the prevention of ataxia and cerebellar defects

➦   Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin actio

➦   In vivo imaging of axonal degeneration and regeneration in the injured spinal cord

➦   Lactadherin promotes VEGF-dependent neovascularization

➦   Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production

➦   PI 3-kinase p110β: a new target for antithrombotic therapy

➦   Integrin αvβ3 is a coreceptor for human cytomegalovirus

➦   Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

➦   Thromboxane A2 and prostaglandin F2α mediate inflammatory tachycardia

➦   Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus

➦   Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice

➦   ATM regulates target switching to escalating doses of radiation in the intestines

➦   A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

➦   Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression anal

➦   Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in tra

➦   Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human n

➦   TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells

➦   Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo

➦   Reversing systemic inflammatory response syndrome with chemokine receptor pepducins

➦   Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

➦   Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and vir

➦   Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity

➦   Inflammatory arthritis requires Foxo3a to prevent Fas ligand–induced neutrophil apoptosis

➦   Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors

➦   Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia

➦   A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin

➦   Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

➦   Smallpox vaccine–induced antibodies are necessary and sufficient for protection against monkeypox vi

➦   Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses

➦   Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

➦   Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination

➦   Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversibl

➦   A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression

➦   Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glu

➦   Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases

➦   Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt ab

➦   Genomic instability in laminopathy-based premature aging

➦   A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

➦   Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis

➦   Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

➦   The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy

➦   Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell respo

➦   Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes T