➦   Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clini

➦   Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induce

➦   Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their nic

➦   Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAI

➦   Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammatio

➦   Protein carbamylation links inflammation, smoking, uremia and atherogenesis

➦   27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

➦   Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

➦   Catching bird flu in a droplet

➦   Central control of bone remodeling by neuromedin U

➦   In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide

➦   Adaptive immune cells temper initial innate responses

➦   Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

➦   Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet t

➦   LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experiment

➦   Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes

➦   Deacetylase inhibition promotes the generation and function of regulatory T cells

➦   STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by

➦   Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic

➦   CD16 promotes Escherichia coli sepsis through an FcRγ inhibitory pathway that prevents phagocytosis

➦   TLR4 enhances TGF-β signaling and hepatic fibrosis

➦   Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

➦   Inhibition of FcεRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes

➦   Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and s

➦   B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates

➦   A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

➦   Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apo

➦   Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectr

➦   Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1

➦   Extralymphatic virus sanctuaries as a consequence of potent T-cell activation

➦   Identification of novel cytolytic peptides as key virulence determinants for community-associated MR

➦   Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the cent

➦   T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor reject

➦   A pivotal role for galectin-1 in fetomaternal tolerance

➦   Pim-1 regulates cardiomyocyte survival downstream of Akt

➦   Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection

➦   Antidepressant actions of the exercise-regulated gene VGF

➦   The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

➦   PPAR-γ regulates osteoclastogenesis in mice

➦   Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease

➦   In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bac

➦   Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and tran

➦   The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibrobl

➦   Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

➦   Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes

➦   Purging metastases in lymphoid organs using a combination of antigen-nonspecific adoptive T cell the

➦   G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension

➦   Modification of kidney barrier function by the urokinase receptor

➦   Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedily

➦   Langerhans cell histiocytosis reveals a new IL-17A–dependent pathway of dendritic cell fusion